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Table 4 Organ/tissue distribution of pept1a (slc15a1a) and pept1b (slc15a1b) mRNA in teleost fish species for which the expression of the two genes has contemporarily been studied. Whenever co-analyzed pept2 (slc15a2) mRNA expression has also been considered

From: The peptide transporter 1a of the zebrafish Danio rerio, an emerging model in nutrigenomics and nutrition research: molecular characterization, functional properties, and expression analysis

Species [order]Developmental stageDescriptionGenBank Acc. No.Organ/tissue distribution (observed in the study)Distribution along the post-gastric alimentary canal (observed in the study)NotesReferences
Mummichog (Fundulus heteroclitus) [Cyprinodontiformes]Adults (~ 9 g)pept1a (slc15a1a)JN615008.1IntestineAnterior intestine ≈ posterior intestineEnvironmental (freshwater acclimation vs. seawater acclimation) and nutritional (fasting vs. re-feeding) regulation of pept1a (slc15a1a) and pept1b (slc15a1b)[43]
pept1b (slc15a1b)JN615007.1Anterior intestine ≈ posterior intestine
Nile Tilapia (Oreochromis niloticus) [Cichliformes]Juveniles (~ 12 g)pept1a (slc15a1a)XM_005452882Intestine >>> stomach > brain > gill > liverProximal intestine >> mid intestine >>> distal intestineEnvironmental (waterborne copper exposure) and/or nutritional (fasting vs. re-feeding) regulation of pept1a (slc15a1a), pept1b (slc15a1b) and pept2 (slc15a2)[44]
pept1b (slc15a1b)XM_005465251Intestine >>> brain ≈ stomachMid intestine > proximal intestine >>> distal intestine
pept2 (slc15a2)XM_005475385Intestine >> stomach > kidney > liver ≥ gill ≈ brain > spleen > muscleMid intestine >>> distal intestine > proximal intestine
Adults (~ 62 g)pept1a (slc15a1a)XM_013267250.1IntestineAnterior intestine > middle intestine >>>> posterior intestineEnvironmental (high-salinity acclimation) regulation of pept1b (slc15a1b)[45]
pept1b (slc15a1b)XM_005452882.2Anterior intestine ≈ middle intestine >>>> posterior intestine
pept2 (slc15a2)XM_005475385Posterior intestine > middle intestine >> anterior intestine
Adults (~ 125 g)pept1a (slc15a1a)XM_003459630IntestineAnterior intestine > middle intestine >>> posterior intestineNutritional (dietary salt supplementation) regulation of pept1a (slc15a1a), pept1b (slc15a1b) and pept2 (slc15a2)[46]
pept1b (slc15a1b)XM_003447363Middle intestine > anterior intestine >>> posterior intestine
pept2 (slc15a2)XM_003454878Posterior intestine ≥ middle intestine >> anterior intestine
Mozambique tilapia (Oreochromis mossambicus) [Cichliformes]Adults (~ 97 g)pept1a (slc15a1a)XM_003459630IntestineAnterior and middle intestineEnvironmental (salinity-dependent) nutritional regulation of pept1a (slc15a1a), pept1b (slc15a1b) and pept2 (slc15a2)[47]
pept1b (slc15a1b)XM_003447363Anterior and middle intestine
pept2 (slc15a2)XM_003454878Middle and posterior intestine
Adults (100–250 g)pept1a (slc15a1a)LC197343IntestineHepatic loop > proximal major coil >>> gastric loop ≈ distal major coil ≈ terminal segmentNutritional (fasting vs. re-feeding) regulation of pept1a (slc15a1a)[48]
Adults (~ 24 g)pept1a (slc15a1a)XM_013267250.1IntestineAnterior intestine > middle intestine >>>> posterior intestineEnvironmental (high-salinity acclimation) regulation of pept1a (slc15a1a) and pept2 (slc15a2)[45]
pept1b (slc15a1b)XM_005452882.2Anterior intestine ≈ middle intestine >>>> posterior intestine
pept2 (slc15a2)XM_005475385Posterior intestine > middle intestine >> anterior intestine
Adults (~ 54 g)pept1a (slc15a1a)KX034112.1Intestine >>>> pituitary ≈ skin ≈ muscle ≈ kidney ≥ heart ≈ brain ≈ gills ≥ liver ≈ fat ≥ stomach ≈ esophagus ≈ spleenAnterior intestine >>> middle intestine >> posterior intestine[49]
pept1b (slc15a1b)KX034110.1Intestine >>>> brain > pituitary > muscle > skin ≈ gills ≈ heart ≈ liver ≈ fat ≈ spleen ≈ kidney ≈ esophagus ≈ stomachAnterior intestine >>>> middle intestine > posterior intestine
pept2 (slc15a2)KX034111.1Intestine ≥ kidney >> muscle ≥ liver > brain ≈ pituitary ≈ skin ≈ stomach > heart ≈ spleen ≈ heart > gillsMiddle intestine >>>> posterior intestine >> anterior intestine
Pre-feeding larvae (3–14 dpf)pept1a (slc15a1a)KX034112.1IntestineWhole intestineTemporal (time course from the pre-hatching to completion of yolk sac resorption stage) regulation of pept1a (slc15a1a), pept1b (slc15a1b) and pept2 (slc15a2)
pept1b (slc15a1b)KX034110.1
pept2 (slc15a2)KX034111.1
European seabass (Dicentrarchus labrax) [Perciformes]Juveniles (~ 1.2 g)pept1a (slc15a1a)IntestineWhole intestineEnvironmental (short- and long-term low-salinity acclimation) regulation of pept1a (slc15a1a), pept1b (slc15a1b) and pept2 (slc15a2)[50]
pept1b (slc15a1b)
pept2 (slc15a2)
  1. Assayed by quantitative real-time PCR, dpf days post-fertilization