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| Sequences | Diversity and richness |
|---|
| | Valid | Normalization | OTU | Coverage (%) | Ace | Chao | Shannon | Simpson |
|---|
| NC | 381,500 | 300,670 | 3618 | 99.77 ± 0.00 | 404.73 ± 17.71 | 406.27 ± 19.92 | 4.09 ± 0.14 | 0.04 ± 0.01 |
| NC-AB | 385,442 | 300,670 | 654 | 99.89 ± 0.00 | 143.14 ± 37.31* | 108.87 ± 22.21* | 2.00 ± 0.14* | 0.19 ± 0.03* |
| DIO | 372,402 | 300,670 | 3314 | 99.77 ± 0.00 | 380.34 ± 19.30* | 379.55 ± 23.48* | 4.26 ± 0.15* | 0.03 ± 0.01* |
| DIO-AB | 365,196 | 300,670 | 474 | 99.91 ± 0.00 | 120.19 ± 48.38*# | 87.36 ± 30.22*# | 1.57 ± 0.09*# | 0.24 ± 0.03*# |
- Three to 4-week-old C57BL/6J male mice were fed a high-fat diet to induce obesity (DIO group) for 16 weeks, with a normal-fat diet as control (NC group). Meanwhile, ampicillin (1 g/L) and neomycin (0.5 g/L) were delivered via drinking water to mice fed the high-fat diet (DIO-AB group) and the normal-fat diet (NC-AB group). Fecal microbiota was analyzed by 16S rRNA high-throughput sequencing. The number of OTUs, coverage percentages, richness estimators (ACE and Chao), and diversity indices (Shannon and Simpson) were calculated at 3% distance. n = 10 in each group. Data are means ± SD
- *Compared to the NC group, P < 0.05
- #Compared to the DIO group, P < 0.05
