Articles

FTO genotype, dietary protein intake, and body weight in a multiethnic population of young adults: a cross-sectional study

Variation in the fat mass and obesity-associated gene (FTO) has been associated with susceptibility to obesity, but the association appears to be modified by diet. We investigated whether dietary protein intake m...

Authors: David C. Merritt, Joseph Jamnik and Ahmed El-Sohemy

Guidelines for Biomarker of Food Intake Reviews (BFIRev): how to conduct an extensive literature search for biomarker of food intake discovery

Identification of new biomarkers of food and nutrient intake has developed fast over the past two decades and could potentially provide important new tools for compliance monitoring and dietary intake assessme...

Authors: Giulia Praticò, Qian Gao, Augustin Scalbert, Guy Vergères, Marjukka Kolehmainen, Claudine Manach, Lorraine Brennan, Sri Harsha Pedapati, Lydia A. Afman, David S. Wishart, Rosa Vázquez-Fresno, Cristina Andres-Lacueva, Mar Garcia-Aloy, Hans Verhagen, Edith J. M. Feskens and Lars O. Dragsted

An update on vitamin B12-related gene polymorphisms and B12 status

Vitamin B12 is an essential micronutrient in humans needed for health maintenance. Deficiency of vitamin B12 has been linked to dietary, environmental and genetic factors. Evidence for the genetic basis of vit...

Authors: S. Surendran, A. Adaikalakoteswari, P. Saravanan, I. A. Shatwaan, J. A. Lovegrove and K. S. Vimaleswaran

Genetic polymorphisms of antioxidant enzymes CAT and SOD affect the outcome of clinical, biochemical, and anthropometric variables in people with obesity under a dietary intervention

Genetic polymorphisms of antioxidant enzymes CAT, GPX, and SOD are involved in the etiology of obesity and its principal comorbidities. The aim of the present study was to analyze the effect of aforementioned ...

Authors: César Hernández-Guerrero, Alicia Parra-Carriedo, Diana Ruiz-de-Santiago, Oscar Galicia-Castillo, Mario Buenrostro-Jáuregui and Carmen Díaz-Gutiérrez

Proposed guidelines to evaluate scientific validity and evidence for genotype-based dietary advice

Nutrigenetic research examines the effects of inter-individual differences in genotype on responses to nutrients and other food components, in the context of health and of nutrient requirements. A practical ap...

Authors: Keith A. Grimaldi, Ben van Ommen, Jose M. Ordovas, Laurence D. Parnell, John C. Mathers, Igor Bendik, Lorraine Brennan, Carlos Celis-Morales, Elisa Cirillo, Hannelore Daniel, Brenda de Kok, Ahmed El-Sohemy, Susan J. Fairweather-Tait, Rosalind Fallaize, Michael Fenech, Lynnette R. Ferguson…

A scheme for a flexible classification of dietary and health biomarkers

Biomarkers are an efficient means to examine intakes or exposures and their biological effects and to assess system susceptibility. Aided by novel profiling technologies, the biomarker research field is underg...

Authors: Qian Gao, Giulia Praticò, Augustin Scalbert, Guy Vergères, Marjukka Kolehmainen, Claudine Manach, Lorraine Brennan, Lydia A. Afman, David S. Wishart, Cristina Andres-Lacueva, Mar Garcia-Aloy, Hans Verhagen, Edith J. M. Feskens and Lars O. Dragsted

Fructose ingestion impairs expression of genes involved in skeletal muscle’s adaptive response to aerobic exercise

The inverse relationship between exercise capacity and its variation over time and both cardiovascular and all-cause mortality suggests the existence of an etiological nexus between cardiometabolic diseases an...

Authors: Natalia Gomes Gonçalves, Stephanie Heffer Cavaletti, Carlos Augusto Pasqualucci, Milton Arruda Martins and Chin Jia Lin

Ranges of phenotypic flexibility in healthy subjects

A key feature of metabolic health is the ability to adapt upon dietary perturbations. A systemic review defined an optimal nutritional challenge test, the “PhenFlex test” (PFT). Recently, it has been shown tha...

Authors: T. J. van den Broek, G. C. M. Bakker, C. M. Rubingh, S. Bijlsma, J. H. M. Stroeve, B. van Ommen, M. J. van Erk and S. Wopereis

Synbiotic effects of β-glucans from cauliflower mushroom and Lactobacillus fermentum on metabolic changes and gut microbiome in estrogen-deficient rats

We investigated whether the long-term consumption of a symbiotic formulation with Lactobacillus fermentum (probiotic) and β-glucan from cauliflower mushroom (prebiotic) would delay the progression of post-menopau...

Authors: Seong-Yeop Jeong, Suna Kang, Cao Shi Hua, Zhang Ting and Sunmin Park

A prospective study of dietary and supplemental zinc intake and risk of type 2 diabetes depending on genetic variation in SLC30A8

The solute carrier family 30 member 8 gene (SLC30A8) encodes a zinc transporter in the pancreatic beta cells and the major C-allele of a missense variant (rs13266634; C/T; R325W) in SLC30A8 is associated with an ...

Authors: Isabel Drake, George Hindy, Ulrika Ericson and Marju Orho-Melander

Gene-nutrient interactions and susceptibility to human obesity

A large number of genome-wide association studies, transferability studies, and candidate gene studies performed in diverse populations around the world have identified gene variants that are associated with c...

Authors: Joseph J. Castillo, Robert A. Orlando and William S. Garver

Ancestors’ dietary patterns and environments could drive positive selection in genes involved in micronutrient metabolism—the case of cofactor transporters

During evolution, humans colonized different ecological niches and adopted a variety of subsistence strategies that gave rise to diverse selective pressures acting across the genome. Environmentally induced se...

Authors: Silvia Parolo, Sébastien Lacroix, Jim Kaput and Marie-Pier Scott-Boyer

Amino acid supplements and metabolic health: a potential interplay between intestinal microbiota and systems control

Dietary supplementation of essential amino acids (EAAs) has been shown to promote healthspan. EAAs regulate, in fact, glucose and lipid metabolism and energy balance, increase mitochondrial biogenesis, and mai...

Authors: Francesco Bifari, Chiara Ruocco, Ilaria Decimo, Guido Fumagalli, Alessandra Valerio and Enzo Nisoli

Does dietary fat affect inflammatory markers in overweight and obese individuals?—a review of randomized controlled trials from 2010 to 2016

Obesity, a major cause of death and disability, is increasing worldwide. Obesity is characterized by a chronic, low-grade inflammatory state which is suggested to play a critical role in the development of obe...

Authors: Vibeke H. Telle-Hansen, Jacob J. Christensen, Stine M. Ulven and Kirsten B. Holven

Impact of supplementation with a food-derived microbial community on obesity-associated inflammation and gut microbiota composition

Obesity is a complex pathology associated with dysbiosis, metabolic alterations, and low-grade chronic inflammation promoted by immune cells, infiltrating and populating the adipose tissue. Probiotic supplemen...

Authors: Marianna Roselli, Chiara Devirgiliis, Paola Zinno, Barbara Guantario, Alberto Finamore, Rita Rami and Giuditta Perozzi

Dietary and health biomarkers—time for an update

In the dietary and health research area, biomarkers are extensively used for multiple purposes. These include biomarkers of dietary intake and nutrient status, biomarkers used to measure the biological effects...

Authors: Lars O. Dragsted, Qian Gao, Giulia Praticò, Claudine Manach, David S. Wishart, Augustin Scalbert and Edith J. M. Feskens

Role of microRNAs in obesity and obesity-related diseases

In recent years, the link between regulatory microRNAs (miRNAs) and diseases has been the object of intensive research. miRNAs have emerged as key mediators of metabolic processes, playing crucial roles in mai...

Authors: Giuseppe Iacomino and Alfonso Siani

Short-term dietary methionine supplementation affects one-carbon metabolism and DNA methylation in the mouse gut and leads to altered microbiome profiles, barrier function, gene expression and histomorphology

Methionine, a central molecule in one-carbon metabolism, is an essential amino acid required for normal growth and development. Despite its importance to biological systems, methionine is toxic when administer...

Authors: Isabelle R. Miousse, Rupak Pathak, Sarita Garg, Charles M. Skinner, Stepan Melnyk, Oleksandra Pavliv, Howard Hendrickson, Reid D. Landes, Annie Lumen, Alan J. Tackett, Nicolaas E.P. Deutz, Martin Hauer-Jensen and Igor Koturbash

Multi-parameter comparison of a standardized mixed meal tolerance test in healthy and type 2 diabetic subjects: the PhenFlex challenge

A key feature of metabolic health is the ability to adapt upon dietary perturbations. Recently, it was shown that metabolic challenge tests in combination with the new generation biomarkers allow the simultane...

Authors: Suzan Wopereis, Johanna H. M. Stroeve, Annette Stafleu, Gertruud C. M. Bakker, Jacobus Burggraaf, Marjan J. van Erk, Linette Pellis, Ruud Boessen, Alwine A. F. Kardinaal and Ben van Ommen

Lactase persistence in Tunisia as a result of admixture with other Mediterranean populations

The ability to digest lactose after weaning, namely, lactase persistence (LP), is encoded by polymorphisms in the MCM6 gene and varies widely in frequency among different human populations. Although, evolution of...

Authors: Yosra Ben Halima, Rym Kefi, Marco Sazzini, Cristina Giuliani, Sara De Fanti, Chokri Nouali, Majdi Nagara, Giacomo Mengozzi, Sahar Elouej, Abdelmajid Abid, Henda Jamoussi, Lotfi Chouchane, Giovanni Romeo, Sonia Abdelhak and Donata Luiselli

Bioavailability of transgenic microRNAs in genetically modified plants

Transgenic expression of small RNAs is a prevalent approach in agrobiotechnology for the global enhancement of plant foods. Meanwhile, emerging studies have, on the one hand, emphasized the potential of transg...

Authors: Jian Yang, Cecilia Primo, Ismail Elbaz-Younes and Kendal D. Hirschi

Formidable challenges to the notion of biologically important roles for dietary small RNAs in ingesting mammals

The notion of uptake of active diet-derived small RNAs (sRNAs) in recipient organisms could have significant implications for our understanding of oral therapeutics and nutrition, for the safe use of RNA inter...

Authors: Stephen Y. Chan and Jonathan W. Snow

Examining for an association between candidate gene polymorphisms in the metabolic syndrome components on excess weight and adiposity measures in youth: a cross-sectional study

A polymorphism in a gene may exert its effects on multiple phenotypes. The aim of this study is to explore the association of 10 metabolic syndrome candidate genes with excess weight and adiposity and evaluate...

Authors: Angélica María Muñoz, Claudia María Velásquez, Gloria María Agudelo, Rosa Magdalena Uscátegui, Alejandro Estrada, Fredy Alonso Patiño, Beatriz Elena Parra, María Victoria Parra and Gabriel Bedoya

Navigating dietary small RNAs

When a novel nutritional concept comes along, scientists become enthusiastic and start new explorations. In 2012, the field was enthralled with a study suggesting plant-based nucleic acid “information” acts as...

Authors: Kendal D. Hirschi

Diet-derived microRNAs: unicorn or silver bullet?

In ancient lore, a bullet cast from silver is the only effective weapon against monsters. The uptake of active diet-derived microRNAs (miRNAs) in consumers may be the silver bullet long sought after in nutriti...

Authors: Kenneth W. Witwer and Chen-Yu Zhang

Milk exosomes: beyond dietary microRNAs

Extracellular vesicles deliver a variety of cargos to recipient cells, including the delivery of cargos in dietary vesicles from bovine milk to non-bovine species. The rate of discovery in this important line ...

Authors: Janos Zempleni

Obesity and microbiota: an example of an intricate relationship

It is widely accepted that metabolic disorders, such as obesity, are closely linked to lifestyle and diet. Recently, the central role played by the intestinal microbiota in human metabolism and in progression ...

Authors: Sabrina Duranti, Chiara Ferrario, Douwe van Sinderen, Marco Ventura and Francesca Turroni

Folate deficiency as predisposing factor for childhood leukaemia: a review of the literature

Folic acid and its derivates, known as folates, are chemoprotective micronutrients of great interest because of their essential role in the maintenance of health and genomic integrity. The supplementation of f...

Authors: Catia Daniela Cantarella, Denise Ragusa, Marco Giammanco and Sabrina Tosi

Enrichment of in vivo transcription data from dietary intervention studies with in vitro data provides improved insight into gene regulation mechanisms in the intestinal mucosa

Gene expression profiles of intestinal mucosa of chickens and pigs fed over long-term periods (days/weeks) with a diet rich in rye and a diet supplemented with zinc, respectively, or of chickens after a one-da...

Authors: Marcel Hulst, Alfons Jansman, Ilonka Wijers, Arjan Hoekman, Stéphanie Vastenhouw, Marinus van Krimpen, Mari Smits and Dirkjan Schokker

Transcriptomic responses of the liver and adipose tissues to altered carbohydrate-fat ratio in diet: an isoenergetic study in young rats

To elucidate the effects of altered dietary carbohydrate and fat balance on liver and adipose tissue transcriptomes, 3-week-old rats were fed three kinds of diets: low-, moderate-, and high-fat diets (L, M, an...

Authors: Mitsuru Tanaka, Akihito Yasuoka, Manae Shimizu, Yoshikazu Saito, Kei Kumakura, Tomiko Asakura and Toshitada Nagai

Brain xanthophyll content and exploratory gene expression analysis: subspecies differences in rhesus macaque

The dietary xanthophylls, lutein and zeaxanthin, accumulate in primate retina and brain, and emerging evidence indicates neural lutein content may be beneficial for cognition. Neural xanthophyll content in pri...

Authors: Emily S. Mohn, John W. Erdman Jr., Martha Neuringer, Matthew J. Kuchan and Elizabeth J. Johnson

Gene expression is differentially regulated in skeletal muscle and circulating immune cells in response to an acute bout of high-load strength exercise

High-intensity exercise induces many metabolic responses. In is unknown whether the response in the peripheral blood mononuclear cells (PBMCs) reflects the response in skeletal muscle and whether mRNA expressi...

Authors: Gyrd O. Gjevestad, Håvard Hamarsland, Truls Raastad, Inger Ottestad, Jacob J. Christensen, Kristin Eckardt, Christian A. Drevon, Anne S. Biong, Stine M. Ulven and Kirsten B. Holven

Effect of different concentrations of omega-3 fatty acids on stimulated THP-1 macrophages

Inflammation plays a central role in chronic diseases occurring in the contemporary society. The health benefits of omega-3 (n-3) fatty acids (FAs), mostly eicosapentaenoic acid (EPA) and docosahexaenoic acid ...

Authors: B. Allam-Ndoul, F. Guénard, O. Barbier and M-C Vohl

Food components and contaminants as (anti)androgenic molecules

Androgens, the main male sex steroids, are the critical factors responsible for the development of the male phenotype during embryogenesis and for the achievement of sexual maturation and puberty. In adulthood...

Authors: Daniele Marcoccia, Marco Pellegrini, Marco Fiocchetti, Stefano Lorenzetti and Maria Marino

The impact of micronutrient status on health: correlation network analysis to understand the role of micronutrients in metabolic-inflammatory processes regulating homeostasis and phenotypic flexibility

Vitamins and carotenoids are key micronutrients facilitating the maintenance of health, as evidenced by the increased risk of disease with low intake. Optimal phenotypic flexibility, i.e., the ability to respo...

Authors: Tim J. van den Broek, Bas H. A. Kremer, Marisa Marcondes Rezende, Femke P. M. Hoevenaars, Peter Weber, Ulrich Hoeller, Ben van Ommen and Suzan Wopereis

A porcine gluteus medius muscle genome-wide transcriptome analysis: dietary effects of omega-6 and omega-3 fatty acids on biological mechanisms

The level of omega-6 and omega-3 polyunsaturated fatty acids can affect many cellular systems and function via nuclear receptors or the bioactive lipid regulation of gene expression. The objective of this stud...

Authors: Magdalena Ogłuszka, Agnieszka Szostak, Marinus F. W. te Pas, Ewa Poławska, Paweł Urbański, Tadeusz Blicharski, Chandra S. Pareek, Edyta Juszczuk-Kubiak, Jenelle R. Dunkelberger, Jarosław O. Horbańczuk and Mariusz Pierzchała

Propelling the paradigm shift from reductionism to systems nutrition

The complex physiology of living organisms represents a challenge for mechanistic understanding of the action of dietary bioactives in the human body and of their possible role in health and disease. Animal, c...

Authors: Jim Kaput, Giuditta Perozzi, Marijana Radonjic and Fabio Virgili

Effect of high carbohydrate diet on elongase and desaturase activity and accompanying gene expression in rat’s liver

Hepatic fatty acids (FAs) are modified through different metabolic pathways including elongation and desaturation. These processes are catalyzed by elongases and desaturases, respectively. Glucose, by transcri...

Authors: Jagoda Drąg, Anna Goździalska, Małgorzata Knapik-Czajka, Anna Gawędzka, Katarzyna Gawlik and Jerzy Jaśkiewicz

Protein-restricted diet during pregnancy after insemination alters behavioral phenotypes of the progeny

Epidemiological studies suggest that hyponutrition during the fetal period increases the risk of mental disorders such as attention deficit hyperactivity disorder and autism-spectrum disorder, which has been e...

Authors: Tamio Furuse, Kunio Miyake, Takashi Kohda, Hideki Kaneda, Takae Hirasawa, Ikuko Yamada, Tomoko Kushida, Misho Kashimura, Kimio Kobayashi, Fumitoshi Ishino, Takeo Kubota and Shigeharu Wakana

Tocotrienols induce endoplasmic reticulum stress and apoptosis in cervical cancer cells

We have previously reported that γ- and δ-tocotrienols (γ- and δ-T3) induce gene expression and apoptosis in human breast cancer cells (MDA-MB-231 and MCF-7). This effect is mediated, at least in part, by a sp...

Authors: Raffaella Comitato, Barbara Guantario, Guido Leoni, Kalanithi Nesaretnam, Maria Beatrice Ronci, Raffaella Canali and Fabio Virgili

Erratum to: 18β-Glycyrrhetinic acid exerts protective effects against cyclophosphamide-induced hepatotoxicity: potential role of PPARγ and Nrf2 upregulation

Authors: Ayman M. Mahmoud and Hussein S. Al Dera

Time-course microarray analysis for identifying candidate genes involved in obesity-associated pathological changes in the mouse colon

Obesity is known to increase the risk of colorectal cancer. However, mechanisms underlying the pathogenesis of obesity-induced colorectal cancer are not completely understood. The purposes of this study were t...

Authors: Yun Jung Bae, Sung-Eun Kim, Seong Yeon Hong, Taesun Park, Sang Gyu Lee, Myung-Sook Choi and Mi-Kyung Sung

Hepatic transcriptome implications for palm fruit juice deterrence of type 2 diabetes mellitus in young male Nile rats

The Nile rat (NR, Arvicanthis niloticus) is a model of carbohydrate-induced type 2 diabetes mellitus (T2DM) and the metabolic syndrome. A previous study found that palm fruit juice (PFJ) delayed or prevented diab...

Authors: Soon-Sen Leow, Julia Bolsinger, Andrzej Pronczuk, K. C. Hayes and Ravigadevi Sambanthamurthi

Improper hydration induces global gene expression changes associated with renal development in infant mice

The kidney is a major organ in which fluid balance and waste excretion is regulated. For the kidney to achieve maturity with functions, normal renal developmental processes need to occur. Comprehensive genetic...

Authors: Chong-Su Kim and Dong-Mi Shin

The effect of maternal undernutrition on the rat placental transcriptome: protein restriction up-regulates cholesterol transport

Fetal exposure to a maternal low protein diet during rat pregnancy is associated with hypertension, renal dysfunction and metabolic disturbance in adult life. These effects are present when dietary manipulatio...

Authors: Zoe Daniel, Angelina Swali, Richard Emes and Simon C Langley-Evans

Effect of diets supplemented with different conjugated linoleic acid (CLA) isomers on protein expression in C57/BL6 mice

The individual genetic variations, as a response to diet, have recently caught the attention of several researchers. In addition, there is also a trend to assume food containing beneficial substances, or to su...

Authors: L. Della Casa, E. Rossi, C. Romanelli, L. Gibellini and A. Iannone

The impact of MTHFR 677C → T risk knowledge on changes in folate intake: findings from the Food4Me study

It is hypothesised that individuals with knowledge of their genetic risk are more likely to make health-promoting dietary and lifestyle changes. The present study aims to test this hypothesis using data from t...

Authors: Clare B. O’Donovan, Marianne C. Walsh, Hannah Forster, Clara Woolhead, Carlos Celis-Morales, Rosalind Fallaize, Anna L. Macready, Cyril F. M. Marsaux, Santiago Navas-Carretero, Rodrigo San-Cristobal, Silvia Kolossa, Christina Mavrogianni, Christina P. Lambrinou, George Moschonis, Magdalena Godlewska, Agnieszka Surwillo…

Erratum to: Fatty acid extract from CLA-enriched egg yolks can mediate transcriptome reprogramming of MCF-7 cancer cells to prevent their growth and proliferation

Authors: Aneta A. Koronowicz, Paula Banks, Dominik Domagała, Adam Master, Teresa Leszczyńska, Ewelina Piasna, Mariola Marynowska and Piotr Laidler

Linkage and association analysis of circulating vitamin D and parathyroid hormone identifies novel loci in Alaska Native Yup’ik people

Vitamin D deficiency is a well-documented public health issue with both genetic and environmental determinants. Populations living at far northern latitudes are vulnerable to vitamin D deficiency and its healt...

Authors: Stella Aslibekyan, Laura K. Vaughan, Howard W. Wiener, Bertha A. Hidalgo, Dominick J. Lemas, Diane M. O’Brien, Scarlett E. Hopkins, Kimber L. Stanhope, Peter J. Havel, Kenneth E. Thummel, Bert B. Boyer and Hemant K. Tiwari

Fatty acid extract from CLA-enriched egg yolks can mediate transcriptome reprogramming of MCF-7 cancer cells to prevent their growth and proliferation

Our previous study showed that fatty acids extract obtained from CLA-enriched egg yolks (EFA-CLA) suppressed the viability of MCF-7 cancer cell line more effectively than extract from non-enriched egg yolks (E...

Authors: Aneta A. Koronowicz, Paula Banks, Dominik Domagała, Adam Master, Teresa Leszczyńska, Ewelina Piasna, Mariola Marynowska and Piotr Laidler