Articles

Coordinated regulation of hepatic and adipose tissue transcriptomes by the oral administration of an amino acid mixture simulating the larval saliva of Vespa species

VAAM is an amino acid mixture that simulates the composition of Vespa larval saliva. VAAM enhanced physical endurance of mice and have been used by athletes as a supplementary drink before exercise. However, ther...

Authors: Fumika Shinozaki, Takashi Abe, Asuka Kamei, Yuki Watanabe, Akihito Yasuoka, Kosuke Shimada, Kaori Kondo, Soichi Arai, Kota Kumagai, Takashi Kondo and Keiko Abe

Genetic susceptibility to dyslipidemia and incidence of cardiovascular disease depending on a diet quality index in the Malmö Diet and Cancer cohort

By taking diet quality into account, we may clarify the relationship between genetically elevated triglycerides (TG) and low-density lipoprotein-cholesterol (LDL-C), and better understand the inconsistent resu...

Authors: Sophie Hellstrand, Ulrika Ericson, Christina-Alexandra Schulz, Isabel Drake, Bo Gullberg, Bo Hedblad, Gunnar Engström, Marju Orho-Melander and Emily Sonestedt

Moderately decreased maternal dietary energy intake during pregnancy reduces fetal skeletal muscle mitochondrial biogenesis in the pigs

Mitochondria are of major importance in oocyte and early embryo, playing a key role in maintaining energy homeostasis. Epidemiological findings indicate that maternal undernutrition-induced mitochondrial dysfu...

Authors: Tiande Zou, Bing Yu, Jie Yu, Xiangbing Mao, Ping Zheng, Jun He, Zhiqing Huang, Yue Liu and Daiwen Chen

Metallothioneins 1 and 2, but not 3, are regulated by nutritional status in rat white adipose tissue

Cumulating evidence underlines the role of adipose tissue metallothionein (MT) in the development of obesity and type 2 diabetes. Fasting/refeeding was shown to affect MT gene expression in the rodent liver. T...

Authors: Sylwia Szrok, Ewa Stelmanska, Jacek Turyn, Aleksandra Bielicka-Gieldon, Tomasz Sledzinski and Julian Swierczynski

Dibutyryl-cAMP affecting fat deposition of finishing pigs by decreasing the inflammatory system related to insulin sensitive or lipolysis

The mechanism of db-cAMP regulating fat deposition and improving lean percentage is unclear and needs to be further studied.

Authors: Xianyong Ma, Wei Fang, Zongyong Jiang, Li Wang, Xuefen Yang and Kaiguo Gao

The PBMC transcriptome profile after intake of oxidized versus high-quality fish oil: an explorative study in healthy subjects

Marine long-chain polyunsaturated fatty acids are susceptible to oxidation, generating a range of different oxidation products with suggested negative health effects. The aim of the present study was to utiliz...

Authors: Mari C. W. Myhrstad, Inger Ottestad, Clara-Cecilie Günther, Einar Ryeng, Marit Holden, Astrid Nilsson, Kirsti W. Brønner, Achim Kohler, Grethe I. A. Borge, Kirsten B. Holven and Stine M. Ulven

Ancient pathogen-driven adaptation triggers increased susceptibility to non-celiac wheat sensitivity in present-day European populations

Non-celiac wheat sensitivity is an emerging wheat-related syndrome showing peak prevalence in Western populations. Recent studies hypothesize that new gliadin alleles introduced in the human diet by replacemen...

Authors: Marco Sazzini, Sara De Fanti, Anna Cherubini, Andrea Quagliariello, Giuseppe Profiti, Pier Luigi Martelli, Rita Casadio, Chiara Ricci, Massimo Campieri, Alberto Lanzini, Umberto Volta, Giacomo Caio, Claudio Franceschi, Enzo Spisni and Donata Luiselli

Liver-specific NG37 overexpression leads to diet-dependent fatty liver disease accompanied by cardiac dysfunction

Environmental factors are well-known causes of diseases. However, aside from a handful of risk indicators, genes’ encoding susceptibility to chronic illnesses and their associated environmental triggers are la...

Authors: Xin Zhou, MengMeng Xu, Liyang Wang, Yulian Mu, Rui Feng, Zhilong Dong, Yuexin Pan, Xunzhang Chen, Yongfeng Liu, Shangen Zheng, Donald D. Anthony, Jianjie Ma, Williams B. Isaacs and Xuehong Xu

Differences in genome-wide gene expression response in peripheral blood mononuclear cells between young and old men upon caloric restriction

Caloric restriction (CR) is considered to increase lifespan and to prevent various age-related diseases in different nonhuman organisms. Only a limited number of CR studies have been performed on humans, and r...

Authors: I. P. G. Van Bussel, A. Jolink-Stoppelenburg, C. P. G. M. De Groot, M. R. Müller and L. A. Afman

Erratum to: The PNPLA3 Ile148Met interacts with overweight and dietary intakes on fasting triglyceride levels

Authors: Ivana A. Stojkovic, Ulrika Ericson, Gull Rukh, Martin Ridderstråle, Stefano Romeo and Marju Orho-Melander

Biomarkers for nutrient intake with focus on alternative sampling techniques

Biomarkers of nutrient intake or nutrient status are important objective measures of foods/nutrients as one of the most important environmental factors people are exposed to. It is very difficult to obtain acc...

Authors: T. Holen, F. Norheim, T. E. Gundersen, P. Mitry, J. Linseisen, P. O. Iversen and C. A. Drevon

Circulating microRNAs are deregulated in overweight/obese children: preliminary results of the I.Family study

MicroRNAs (miRNAs) are small non-coding RNAs involved in the modulation of gene expression and in the control of numerous cell functions. Alterations of miRNA patterns frequently occur in cancer and metabolic ...

Authors: Giuseppe Iacomino, Paola Russo, Ilaria Stillitano, Fabio Lauria, Pasquale Marena, Wolfgang Ahrens, Pasquale De Luca and Alfonso Siani

Several type 2 diabetes-associated variants in genes annotated to WNT signaling interact with dietary fiber in relation to incidence of type 2 diabetes

TCF7L2 is a central transcription factor in the canonical wingless-type MMTV integration site (WNT) signaling pathway, and genetic variants in TCF7L2 have been found to interact with dietary fiber intake on type ...

Authors: George Hindy, Inês G. Mollet, Gull Rukh, Ulrika Ericson and Marju Orho-Melander

Comparative anti-inflammatory and lipid-normalizing effects of metformin and omega-3 fatty acids through modulation of transcription factors in diabetic rats

Emerging evidence suggests beneficial effects of omega-3 fatty acids on diabetic complications. The present study compared the progressive effects of metformin and flax/fish oil on lipid metabolism, inflammato...

Authors: Abhijit Ghadge, Abhay Harsulkar, Manjiri Karandikar, Vijaya Pandit and Aniket Kuvalekar

Effect of a diet enriched with omega-6 and omega-3 fatty acids on the pig liver transcriptome

The optimal ratio of omega-6 to omega-3 polyunsaturated fatty acids (PUFAs) is important for keeping the homeostasis of biological processes and metabolism, yet the underlying biological mechanism is poorly un...

Authors: Agnieszka Szostak, Magdalena Ogłuszka, Marinus F. W. te Pas, Ewa Poławska, Paweł Urbański, Edyta Juszczuk-Kubiak, Tadeusz Blicharski, Chandra Shekhar Pareek, Jenelle R. Dunkelberger, Jarosław O. Horbańczuk and Mariusz Pierzchała

Expression of cardiac insulin signalling genes and proteins in rats fed a high-sucrose diet: effect of bilberry anthocyanin extract

Insulin resistance is associated with impaired cardiac function, but the underlying molecular abnormalities are largely unexplained. Bilberry anthocyanin (BAcn) may be protective, as it appears to potentiate i...

Authors: Shamjeet Singh, Thomas Netticadan and D. Dan Ramdath

Transcriptomic profile adaptations following exposure of equine satellite cells to nutriactive phytochemical gamma-oryzanol

Adult skeletal muscle myogenesis depends on the activation of satellite cells that have the potential to differentiate into new fibers. Gamma-oryzanol (GO), a commercially available nutriactive phytochemical, ...

Authors: K. A. Szcześniak, A. Ciecierska, P. Ostaszewski and T. Sadkowski

Methyl group donors abrogate adaptive responses to dietary restriction in C. elegans

Almost all animals adapt to dietary restriction through alternative life history traits that affect their growth, reproduction, and survival. Economized management of fat stores is a prevalent type of such ada...

Authors: Maja Klapper, Daniel Findeis, Harald Koefeler and Frank Döring

Effects of a healthy Nordic diet on gene expression changes in peripheral blood mononuclear cells in response to an oral glucose tolerance test in subjects with metabolic syndrome: a SYSDIET sub-study

Diet has a great impact on the risk of developing features of metabolic syndrome (MetS), type 2 diabetes mellitus (T2DM), and cardiovascular diseases (CVD). We evaluated whether a long-term healthy Nordic diet...

Authors: Lena Leder, Marjukka Kolehmainen, Ingunn Narverud, Ingrid Dahlman, Mari C. W. Myhrstad, Vanessa D. de Mello, Jussi Paananen, Carsten Carlberg, Ursula Schwab, Karl-Heinz Herzig, Lieselotte Cloetens, Matilda Ulmius Storm, Janne Hukkanen, Markku J. Savolainen, Fredrik Rosqvist, Kjeld Hermansen…

Curcumin and tetrahydrocurcumin both prevent osteoarthritis symptoms and decrease the expressions of pro-inflammatory cytokines in estrogen-deficient rats

Menopausal symptoms are associated with inflammation. Curcumin is a well-known anti-inflammatory bioactive compound from turmeric whereas tetrahydrocurcumin (THC) is a major metabolite of curcumin that may hav...

Authors: Sunmin Park, La Ra Lee, Ji Hyun Seo and Suna Kang

Vitamin A deficiency modulates iron metabolism independent of hemojuvelin (Hfe2) and bone morphogenetic protein 6 (Bmp6) transcript levels

Considering that vitamin A deficiency modulates hepcidin expression and consequently affects iron metabolism, we evaluated the effect of vitamin A deficiency in the expression of genes involved in the hemojuve...

Authors: Juliana Frossard Ribeiro Mendes, Egle Machado de Almeida Siqueira, João Gabriel Marques de Brito e Silva and Sandra Fernandes Arruda

Systems biology approaches to study the molecular effects of caloric restriction and polyphenols on aging processes

Worldwide population is aging, and a large part of the growing burden associated with age-related conditions can be prevented or delayed by promoting healthy lifestyle and normalizing metabolic risk factors. H...

Authors: Sébastien Lacroix, Mario Lauria, Marie-Pier Scott-Boyer, Luca Marchetti, Corrado Priami and Laura Caberlotto

Skeletal muscle mitochondrial uncoupling prevents diabetes but not obesity in NZO mice, a model for polygenic diabesity

Induction of skeletal muscle (SM) mitochondrial stress by expression of uncoupling protein 1 (UCP1) in mice results in a healthy metabolic phenotype associated with increased secretion of FGF21 from SM. Here,...

Authors: Anja Voigt, Yvonne Katterle, Melanie Kahle, Reinhart Kluge, Annette Schürmann, Hans-Georg Joost and Susanne Klaus

Variation in extracellular matrix genes is associated with weight regain after weight loss in a sex-specific manner

The extracellular matrix (ECM) of adipocytes is important for body weight regulation. Here, we investigated whether genetic variation in ECM-related genes is associated with weight regain among participants of...

Authors: Nadia J. T. Roumans, Roel G. Vink, Marij Gielen, Maurice P. Zeegers, Claus Holst, Ping Wang, Arne Astrup, Wim H. Saris, Armand Valsesia, Jörg Hager, Marleen A. van Baak and Edwin C. M. Mariman

Nutritional biology: a neglected basic discipline of nutritional science

On the basis of a scientific-philosophical analysis, this paper tries to show that the approaches in current nutritional science—including its subdisciplines which focus on molecular aspects—are predominantly...

Authors: Frank Döring and Alexander Ströhle

Effects of ferrous carbamoyl glycine on iron state and absorption in an iron-deficient rat model

An iron-deficient rat model was established and used to determine the effects of different iron sources on iron metabolism and absorption. Iron-deficient rats were assigned to one of three treatment groups, an...

Authors: Yuzhe Zhang, Xiaoming Sun, Chunyan Xie, Xugang Shu, Abimbola Oladele Oso, Zheng Ruan, Ze-yuan Deng, Xin Wu and Yulong Yin

A genome-wide association study of n-3 and n-6 plasma fatty acids in a Singaporean Chinese population

Polyunsaturated fatty acids (PUFAs) have a major impact on human health. Recent genome-wide association studies (GWAS) have identified several genetic loci that are associated with plasma levels of n-3 and n-6...

Authors: Rajkumar Dorajoo, Ye Sun, Yi Han, Tingjing Ke, Ayala Burger, Xuling Chang, Hui Qi Low, Weihua Guan, Rozenn N. Lemaitre, Chiea-Chuen Khor, Jian-Min Yuan, Woon-Puay Koh, Choon Nam Ong, E. Shyong Tai, Jianjun Liu, Rob M. van Dam…

A randomized, double-blind, placebo-controlled, clinical trial on probiotic soy milk and soy milk: effects on epigenetics and oxidative stress in patients with type II diabetes

This clinical trial aimed to discover the effects of probiotic soy milk and soy milk on MLH1 and MSH2 promoter methylation, and oxidative stress among type II diabetic patients. Forty patients with type II dia...

Authors: Mitra Hariri, Rasoul Salehi, Awat Feizi, Maryam Mirlohi, Reza Ghiasvand and Nahal Habibi

Coffee provides a natural multitarget pharmacopeia against the hallmarks of cancer

Coffee is the second most popular beverage in the world after water with a consumption of approximately two billion cups per day. Due to its low cost and ease of preparation, it is consumed in almost all coun...

Authors: François Gaascht, Mario Dicato and Marc Diederich

Influence of miRNA-106b and miRNA-135a on butyrate-regulated expression of p21 and Cyclin D2 in human colon adenoma cells

Epigenetic and posttranslational modifications of the expression of cell cycle-relevant genes or proteins like p21, e.g., by miRNAs are crucial mechanisms in the development or prevention of colon cancer. The pr...

Authors: W. Schlörmann, S. Naumann, C. Renner and M. Glei

Metformin and soybean-derived bioactive molecules attenuate the expansion of stem cell-like epithelial subpopulation and confer apoptotic sensitivity in human colon cancer cells

Colorectal cancer (CRC) is a disease whose genesis may include metabolic dysregulation. Cancer stem cells are attractive targets for therapeutic interventions since their aberrant expansion may underlie tumor ...

Authors: Maria Theresa E. Montales, Rosalia C. M. Simmen, Ederlan S. Ferreira, Valdir A. Neves and Frank A. Simmen

Characterization of the hypothalamic transcriptome in response to food deprivation reveals global changes in long noncoding RNA, and cell cycle response genes

The hypothalamus integrates energy balance information from the periphery using different neuronal subtypes within each of the hypothalamic areas. However, the effects of prandial state on global mRNA, microRN...

Authors: Hao Jiang, Thero Modise, Richard Helm, Roderick V. Jensen and Deborah J. Good

GABA selectively increases mucin-1 expression in isolated pig jejunum

The inhibitory neurotransmitter GABA (γ-aminobutyric acid) is synthesized by glutamic acid decarboxylase, which is expressed in the central nervous system and in various other tissues including the intestine. ...

Authors: Hannah-Sophie Braun, Gerhard Sponder, Robert Pieper, Jörg R. Aschenbach and Carolin Deiner

Mulberry leaves (Morus alba L.) ameliorate obesity-induced hepatic lipogenesis, fibrosis, and oxidative stress in high-fat diet-fed mice

Obesity is associated with chronic diseases such as fatty liver, type 2 diabetes, cardiovascular disease, and severe metabolic syndrome. Obesity causes metabolic impairment including excessive lipid accumulat...

Authors: Ji-Young Ann, Hyeyoon Eo and Yunsook Lim

Erratum to: Fasting enriches liver triacylglycerol with n-3 polyunsaturated fatty acids: implications for understanding the adipose–liver axis in serum docosahexaenoic acid regulation

Authors: Kristin A. Marks, Phillip M. Marvyn, Juan J. Aristizabal Henao, Ryan M. Bradley, Ken D. Stark and Robin E. Duncan

Zinc-induced upregulation of metallothionein (MT)-2A is predicted by gene expression of zinc transporters in healthy adults

The usefulness of zinc transporter and metallothionein (MT) gene expressions to detect changes in zinc intake remains unclear. This pilot study aimed to determine the effects of zinc supplementation on zinc tr...

Authors: Anna Chu, Meika Foster, Sarah Ward, Kamrul Zaman, Dale Hancock, Peter Petocz and Samir Samman

Dietary polyunsaturated fatty acids and the Pro12Ala polymorphisms of PPARG regulate serum lipids through divergent pathways: a randomized crossover clinical trial

Human and animal studies suggest an interaction between the Pro12Ala polymorphism of PPARG and dietary fat. In this randomized crossover clinical trial, we investigated whether subjects with the Pro12Pro and Ala...

Authors: Jussi Pihlajamäki, Ursula Schwab, Dorota Kaminska, Jyrki Ågren, Johanna Kuusisto, Marjukka Kolehmainen, Jussi Paananen, Markku Laakso and Matti Uusitupa

Consumer adoption of personalised nutrition services from the perspective of a risk–benefit trade-off

Through a Privacy Calculus (i.e. risk–benefit trade-off) lens, this study identifies factors that contribute to consumers’ adoption of personalised nutrition services. We argue that consumers’ intention to ado...

Authors: Aleksandra Berezowska, Arnout R. H. Fischer, Amber Ronteltap, Ivo A. van der Lans and Hans C. M. van Trijp

18β-Glycyrrhetinic acid exerts protective effects against cyclophosphamide-induced hepatotoxicity: potential role of PPARγ and Nrf2 upregulation

18β-Glycyrrhetinic acid (18β-GA) has been proposed as a promising hepatoprotective agent. The current study aimed to investigate the protective action and the possible mechanisms of 18β-GA against cyclophospha...

Authors: Ayman M. Mahmoud and Hussein S. Al Dera

Multiple effects of curcumin on promoting expression of the exon 7-containing SMN2 transcript

Survival of motor neuron 2 (SMN2) is a modifier gene for spinal muscular atrophy (SMA), a neurodegenerative disease caused by insufficient SMN protein mostly due to SMN1 defect. SMN2 is n...

Authors: Dairong Feng, Yi Cheng, Yan Meng, Liping Zou, Shangzhi Huang and Jiuyong Xie

Fasting enriches liver triacylglycerol with n-3 polyunsaturated fatty acids: implications for understanding the adipose–liver axis in serum docosahexaenoic acid regulation

We investigated the effect of short-term fasting on coordinate changes in the fatty acid composition of adipose triacylglycerol (TAG), serum non-esterified fatty acids (NEFA), liver TAG, and serum TAG and phos...

Authors: Kristin A. Marks, Phillip M. Marvyn, Juan J. Aristizabal Henao, Ryan M. Bradley, Ken D. Stark and Robin E. Duncan

Altered expression of two zinc transporters, SLC30A5 and SLC30A6, underlies a mammary gland disorder of reduced zinc secretion into milk

Two cases of zinc deficiency in breastfed neonates were investigated where zinc levels in the mothers’ milk were reduced by more than 75 % compared to normal. The objective of this study was to find the molec...

Authors: Loveleen Kumar, Agnes Michalczyk, Jill McKay, Dianne Ford, Taiho Kambe, Lee Hudek, George Varigios, Philip E. Taylor and M. Leigh Ackland

Polymorphism in miR-31 and miR-584 binding site in the angiotensinogen gene differentially influences body fat distribution in both sexes

Angiotensinogen (AGT), its active fragments and microRNA-31 (miR-31) play an important role in adipocyte differentiation. AGT contains a miR-31 polymorphic binding site. We hypothesize that the rs7079 polymorp...

Authors: Jan Machal, Jan Novak, Renata Hezova, Filip Zlamal, Anna Vasku, Ondrej Slaby and Julie Bienertova-Vasku

Human nutrition, environment, and health

Authors: Jim Kaput, Martin Kussmann, Marijana Radonjic, Fabio Virgili and Giuditta Perozzi

Integrative network-based analysis of mRNA and microRNA expression in 1,25-dihydroxyvitamin D₃-treated cancer cells

Nutritional systems biology is an evolving research field aimed at understanding nutritional processes at a systems level. It is known that the development of cancer can be influenced by the nutritional status...

Authors: Martina Kutmon, Susan L. Coort, Kim de Nooijer, Claire Lemmens and Chris T. Evelo

Polymorphisms in sweet taste genes (TAS1R2 and GLUT2), sweet liking, and dental caries prevalence in an adult Italian population

The aim of the study was to assess the relationship between sweet taste genes and dental caries prevalence in a large sample of adults. In addition, the association between sweet liking and sugar intake with ...

Authors: Antonietta Robino, Lorenzo Bevilacqua, Nicola Pirastu, Roberta Situlin, Roberto Di Lenarda, Paolo Gasparini and Chiara Ottavia Navarra

Use of miRNAs in biofluids as biomarkers in dietary and lifestyle intervention studies

The selection of biomarkers in nutrigenomics needs to reflect subtle changes in homoeostasis representing the relation between nutrition and health, or nutrition and disease. It is believed that noncoding RNA...

Authors: Sophie Rome

miRNA-regulated gene expression differs in celiac disease patients according to the age of presentation

Celiac disease is an intestinal disease which shows different symptoms and clinical manifestations among pediatric and adult patients. These variations could be imputable to age-related changes in gut architec...

Authors: Gaia Buoli Comani, Roberto Panceri, Marco Dinelli, Andrea Biondi, Clara Mancuso, Raffaella Meneveri and Donatella Barisani

Nutritional systems biology of type 2 diabetes

Type 2 diabetes (T2D) has become an increasingly challenging health burden due to its high morbidity, mortality, and heightened prevalence worldwide. Although dietary and nutritional imbalances have long been ...

Authors: Yuqi Zhao, Rio Elizabeth Barrere-Cain and Xia Yang

Low fruit consumption and folate deficiency are associated with LINE-1 hypomethylation in women of a cancer-free population

Several dietary agents, such as micronutrient and non-nutrient components, the so-called bioactive food components, have been shown to display anticancer properties and influence genetic processes. The most co...

Authors: Antonella Agodi, Martina Barchitta, Annalisa Quattrocchi, Andrea Maugeri, Carolina Canto, Anna Elisa Marchese and Manlio Vinciguerra